80 پرسنٹ شگر کے مریض خون جمنے والی بیماری کے باعث مر جاتے ہیں۔ خون کے کلاٹ کی وجہ سے ہارٹ اٹیک یا فالج یا اور کوئی مہلک مرض جنم لیتا ہے۔ ایسی حالت میں کرومک کلورائیڈ ایسی میڈیسن ہے جو بہت کم سائیڈ افیکٹ والی اور بہت مفید ثابت سکتی ہے۔ یہ چکنائی کے نظام fat metabolism کو بھی درست رکھتی ہے اور بلڈ پریشر، کولیسٹرول کو کنٹرول کر کے ہارٹ اٹیک اور فالج سے بھی بچاتی ہے۔

Eighty percent of patients with diabetes mellitus die a thrombotic death. Seventy-five percent of these deaths is due to cardiovascular complications, and the remainder is due to cerebrovascular events and peripheral vascular complications. Vascular endothelium, the primary defense against thrombosis, is abnormal in diabetes. Endothelial abnormalities undoubtedly play a role in the enhanced activation of platelets and clotting factors seen in diabetes. Coagulation activation markers, such as prothrombin activation fragment 1+2 and thrombin-anti-thrombin complexes, are elevated in diabetes. The plasma levels of many clotting factors including fibrinogen, factor VII, factor VIII, factor XI, factor XII, kallikrein, and von Willebrand factor are elevated in diabetes. Conversely, the level of the anticoagulant protein C (PC) is decreased. The fibrinolytic system, the primary means of removing clots, is relatively inhibited in diabetes due to abnormal clot structures that are more resistant to degradation and an increase in plasminogen activator inhibitor type 1 (PAI-1). Increased circulating platelet aggregates, increased platelet aggregation in response to platelet agonists, increased platelet contractile force (PCF), and the presence of higher plasma levels of platelet release products, such as beta-thromboglobulin, platelet factor 4, and thromboxane B(2), demonstrate platelet hyperactivity in diabetes. This constellation of findings supports the clinical observation that diabetes is a hypercoagulable state. This article briefly reviews the published evidence for this conclusion and the putative roles played by hyperglycemia and hyperinsulinemia in its development.

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